NOT KNOWN FACTUAL STATEMENTS ABOUT TRASTUZUMAB HOW DOES IT WORK

The phosphorylated HER3 presents docking sites for p85 subunit of PI3K. The completely activated PI3K intricate is produced by binding of p110 subunit of PI3K to p85 which is ready to produce PIP3 through phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both equally threonine and seri